Isesengura ryinshi ryamazi yisesengura (HPLC) nubwoko bwa mobile igendanwa ikoresha amazi nkicyiciro cya mobile. Icyitegererezo hamwe na solvent bijyanwa kumurongo wa chromatografi yuzuye icyiciro gihagaze binyuze mumapompo yumuvuduko mwinshi. Ukurikije imbaraga zinyuranye zikorana hagati yibice bitandukanye murugero nicyiciro gihagaze, tekinike ya Chromatic yo gutandukana, isesengura ryujuje ubuziranenge hamwe ninshi. Ifite ibyiza byo gutandukana cyane, umuvuduko wisesengura byihuse, ibyiyumvo byinshi kandi byororoka neza, kandi ikoreshwa cyane muri chimie organic, biohimiki, ubuvuzi, ibiryo, ibidukikije nizindi nzego.